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Published TCIMAIL newest issue No.200
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CAS RN: 594-65-0 | Product Number: T0368
Trichloroacetamide
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Purity: >98.0%(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
€38.00
|
2 | 4 |
|
|
| 500G |
€426.00
|
Contact Us | 26 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T0368 |
Purity / Analysis Method 
|
>98.0%(N) |
| Molecular Formula / Molecular Weight | C__2H__2Cl__3NO = 162.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 594-65-0 |
| Reaxys Registry Number | 1754028 |
| PubChem Substance ID | 87576334 |
| SDBS (AIST Spectral DB) | 3665 |
| MDL Number | MFCD00008009 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 140.0 to 144.0 °C |
Properties (reference)
| Melting Point | 141 °C |
| Boiling Point | 240 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 209-849-3 |
| RTECS# | AC9275000 |
Transport Information:
| HS Number | 2924297099 |
Application
TCI Practical Example: Chlorination of Alkyl Alcohols through Appel Reaction
Used Chemicals
Procedure
To a mixture of 2-phenylethyl alcohol (0.196 mL, 1.64 mmol) and PPh3 (0.859 g, 3.27 mmol) in CH2Cl2 (8.2 mL) at r. t. was added a solution of trichloroacetamide (0.532 g, 3.27 mmol). The reaction mixture was stirred at room temperature for 15 min. The reaction mixture poured into ice water (30 mL), and then, extracted by ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure, and purified by silica gel column chromatography (hexane:ethyl acetate = 7:3) to give (2-chloroethyl)benzene (0.220 g, 97% yield) as a colorless liquid.
Experimenter’s Comments
The reaction mixture was monitored by TLC (hexane:ethyl acetate = 4:1, Rf = 0.7).
Analytical Data
1H NMR (400 MHz, CDCl3); δ 7.36-7.21 (m, 5H), 3.72 (t, 2H, J = 11.2 Hz), 3.07 (t, 2H, J = 11.2 Hz).
13C NMR (101 MHz, CDCl3); δ 138.1, 128.8, 128.6, 126.9, 44.9, 33.2.
Lead Reference
- An efficient method for chlorination of alcohols using PPh3/Cl3CCONH2
PubMed Literature
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