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Published TCIMAIL newest issue No.198
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CAS RN: 147127-20-6 | Product Number: T3006
Tenofovir
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€16.00
|
Contact Us | ≥100 |
|
| 5G |
€51.00
|
3 | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | T3006 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__4N__5O__4P = 287.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 147127-20-6 |
| Reaxys Registry Number | 7415378 |
| PubChem Substance ID | 253660231 |
| Merck Index (14) | 9146 |
| MDL Number | MFCD00943794 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0%(calcd.on anh.substance) |
| Specific rotation [a]20/D | -19.0 to -21.0 deg(C=1, 0.1mol/L HCl)(calcd.on anh.substance) |
| Water | max. 6.0 % |
Properties (reference)
| Melting Point | 283 °C |
| Specific Rotation | -20° (C=1,0.1mol/L HCl) |
GHS
Related Laws:
| RTECS# | SZ6563600 |
Transport Information:
| HS Number | 2933998090 |
Application
Tenofovir: a Nucleotide Reverse Transcriptase (RT) Inhibitor
Tenofovir, also known as PMPA, is a nucleotide reverse transcriptase (RT) inhibitor. It shows activity against hepatitis B virus (HBV) and human immunodeficiency virus (HIV). It is the active metabolite of tenofovir disoproxil fumarate.
References
- Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine
- Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors
- Phosphonomethoxyalkyl analogs of nucleotides
- Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections
- Case history: Acyclic nucleoside phosphonates: a key class of antiviral drugs
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