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CAS RN: 192185-72-1 | Product Number: T4299
Tipifarnib
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Purity: >95.0%(HPLC)
Synonyms:
- 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
€140.00
|
Contact Us | 39 |
|
|
| 25MG |
€490.00
|
Contact Us | 29 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T4299 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__2Cl__2N__4O = 489.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 192185-72-1 |
| Reaxys Registry Number | 9734901 |
| MDL Number | MFCD07772347 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 214.0 to 218.0 °C |
| Specific rotation | +20.0 to +24.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 216 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P314 : Get medical advice/ attention if you feel unwell. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | VC8274507 |
Transport Information:
| HS Number | 2933790090 |
Application
Tipifarnib: A Potent and Selective Inhibitor of Farnesyl Transferase
Farnesyl transferase (FT) regulates the activation of the Ras protein, which consequently affects intracellular signal transduction, cell growth, and proliferation. Tipifarnib (R115777) has been reported to be a potent and selective inhibitor of FT, exhibiting significant antitumor effects in vivo and in vitro. (The product is for research use only.)
References
- Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
- Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery (a review)
- Development of farnesyl transferase inhibitors: a review
- Farnesyl transferase inhibitors (a review)
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