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CAS RN: 869572-92-9 | Product Number: T4378
Tecovirimat
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New
Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-1,3-Dioxo-3,3a,4,4a,5,5a,6,6a-octahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€80.00
|
Contact Us | ≥40 |
|
|
| 50MG |
€250.00
|
Contact Us | ≥40 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T4378 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__9H__1__5F__3N__2O__3 = 376.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 869572-92-9 |
| Reaxys Registry Number | 10723956 |
| MDL Number | MFCD11973644 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2928009090 |
Application
Tecovirimat: An Antiviral Agent against Smallpox and Mpox
Mpox (formerly known as monkeypox) is caused by the Mpox virus (MpoxV), which is an enveloped double-stranded DNA virus of the poxiviridae family and the genus Orthopoxvirus (OPV). Tecovirimat has potent antiviral activity against smallpox and Mpox.1-3) It inhibits the activity of the mature virus vp37 protein, which is essential for forming the extracellular enveloped virus upon cell lysis. Consequently, tecovirimat has been demonstrated to inhibit the production of the extracellular virus, thereby reducing the transmission of virus to distant sites. For your reference, anti-Mpox agents with different mechanisms of action have been reported.1,4) (The product is for research use only.)
References
- 1) VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions (a review)
- 2) Antivirals With Activity Against Mpox: A Clinically Oriented Review
- 3) Monkeypox (mpox) virus: Classification, origin, transmission, genome organization, antiviral drugs, and molecular diagnosis (a review)
- 4) Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease
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