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Published TCIMAIL newest issue No.198
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CAS RN: 55778-02-4 | Product Number: W0017
WZ 811
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Purity: >97.0%(T)
Synonyms:
- N,N'-[1,4-Phenylenebis(methylene)]bis(pyridin-2-amine)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
160,00 €
|
Contact Us | 27 |
|
| 100MG |
432,00 €
|
Contact Us | 35 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | W0017 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__1__8H__1__8N__4 = 290.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 55778-02-4 |
| Reaxys Registry Number | 9335578 |
| PubChem Substance ID | 468593125 |
| MDL Number | MFCD18086914 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 188.0 to 192.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 190 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
WZ811: A CXC Chemokine Receptor Type 4 (CXCR4) Antagonist
WZ811 is known as an antagonist of CXC chemokine receptor type 4 (CXCR4), which is a chemokine receptor expressed on immune cells and cancer cells. CXCR4 is activated by its chemokine ligand CXCL12 (also known as SDF-1), and regulates many physiological and developmental processes such as hematopoietic cell trafficking. .CXCR4 is also one of the main co- receptors for human immunodeficiency virus (HIV) entry into T cells. Recently, it has been reported that CXCR4 induces migration of cancer cells and is important for processes such as metastasis. Therefore, CXCR4 antagonists are expected to regulate these tumor metastatic processes. (The product is for research purpose only.)
References
- Discovery of Small Molecule CXCR4 Antagonists
- Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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