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CAS RN: 298-81-7 | Product Number: X0009
Xanthotoxin
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Purity: >98.0%(GC)
Synonyms:
- Methoxsalen
- 8-Methoxypsoralen
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
16,00 €
|
1 | 6 |
|
| 1G |
43,00 €
|
9 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | X0009 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__2H__8O__4 = 216.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 298-81-7 |
| Reaxys Registry Number | 196453 |
| PubChem Substance ID | 87577878 |
| SDBS (AIST Spectral DB) | 10625 |
| Merck Index (14) | 5988 |
| MDL Number | MFCD00005009 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 145.0 to 149.0 °C |
Properties (reference)
| Melting Point | 147 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 206-066-9 |
| RTECS# | LV1400000 |
Transport Information:
| HS Number | 2932990090 |
Application
8-Methoxypsoralen (8-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA
5-Methoxypsoralen (5-MOP) [B2840], 8-methoxypsoralen (8-MOP) and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2+2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)
References
- The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD (a review)
- 5-Methoxypsoralen: a review of its effects in psoriasis and vitiligo (a review)
- Photoreactivity of Furocoumarins and DNA in PUVA Therapy: Formation of Psoralen−Thymine Adducts
- Psoralen photobiology and photochemotherapy: 50 years of science and medicine (a review)
- Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins
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