Monoaminated & Monotosylated Cyclodextrins

In recent years, there has been much research into CD derivatives having the clathrate ability, but to which a new function is added by introducing functional molecules to a certain position within CD. For example, CD bearing a fluorescent dye moiety as a molecular recognition fluorescent sensor,¹⁾ CD bearing C₆₀²⁾ as water soluble C₆₀, and CD bearing trypsin³⁾ as stabilized trypsin have been reported. As starting materials for the synthesis of these CD derivatives, CD having a certain hydroxyl group, which is activated,⁴⁾ and CD having a certain hydroxyl group converted to an amino group are used.

We have commercially produced CD derivatives in which the primary hydroxyl group at the 6 position of CD is converted to tosyloxy group, the secondary hydroxyl group at the 2 position is converted to tosyloxy group, and the steric configuration of the second hydroxyl group at the 3 position is inverted and converted to an amino group. We hope you will find these materials useful for the synthesis of, and research into, these functional CD derivatives.