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Published TCIMAIL newest issue No.198
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Guanidinylation
No.136(December 2008)
1-Amidinopyrazole hydrochloride (1) reacts with primary and secondary amines to yield the corresponding guanidines.1) Moreover, the N-Boc/Ts-protected guanidine 3 can be also obtained using the corresponding N-Boc/Ts-protected derivative 2.2) It is also reported that a solid phase guanidinylation can be performed using cellulose-suported guanidine compound 4.3)
References
- 1)Guanidinylation of primary amines: synthesis of a 5-HT3 receptor agonist
- 2)Efficient introduction of protected guanidines in solid phase peptide synthesis
- 3)New cellulose-supported guanidinylating reagent
Related Compounds
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