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CAS RN: 154229-18-2 | Product Number: A2891

Abiraterone Acetate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 3β-17-(3-Pyridyl)androsta-5,16-dien-3-ol Acetate
Documents:
200MG
A$418.00
12   1  
1G
A$1,252.00
15   ≥20 
* Please contact our distributor of Chem-Supply if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
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Product Number A2891
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__6H__3__3NO__2 = 391.56  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 154229-18-2
Reaxys Registry Number 7314563
PubChem Substance ID 253661226
MDL Number

MFCD00934213

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 145.0 to 149.0 °C
Specific rotation [a]20/D -40.0 to -45.0 deg(C=2,EtOH)
Properties (reference)
Melting Point 147 °C
Specific Rotation -43° (C=2,EtOH)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# BV7992100
Transport Information:
H.S.code* 2937.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Abiraterone Acetate: A Prodrug of Abiraterone [A2868]

Abiraterone acetate (CB7630) is a prodrug of abiraterone [A2868] which is a selective inhibitor of the steroidogenic enzyme cytochrome P450 17A1 (CYP17A1) which catalyzes two key serial reactions (17α-hydroxylase hydroxylase and 17,20-lyase) in androgen and estrogen biosynthesis. Abiraterone is more potent than ketoconazole [K0045] as an inhibitor of CYP17. Abiraterone acetate is an agent used in combination with prednisone [P1276] in metastatic castration-resistant prostate cancer (mCRPC). (The product is for research purpose only.)

References


PubMed Literature


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