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CAS RN: 546141-08-6 | Product Number: A3607
URB-597
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Purity: >98.0%(T)(HPLC)
Synonyms:
- FAAH Inhibitor II
- 3'-Carbamoyl-[1,1'-biphenyl]-3-yl Cyclohexylcarbamate
- 3'-(Aminocarbonyl)[1,1'-biphenyl]-3-yl N-Cyclohexylcarbamate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
A$246.00
|
26 | 2 | Contact Us |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | A3607 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2N__2O__3 = 338.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 546141-08-6 |
| Reaxys Registry Number | 9795889 |
| MDL Number | MFCD05863934 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2924.29-000 |
Application
URB-597: A Potent and Selective Inhibitor of the Enzyme Fatty Acid Amide Hydrolase (FAAH),
Endogenous cannabinoids, such as anandamide (AEA) [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the CB1 and CB2 cannabinoid receptors. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS), which is involved in a variety of physiological processes. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process mediated by fatty acid amide hydrolase (FAAH) for anandamide and monoacylglycerol lipase (MAGL) for 2-AG. URB-597 (KDS-4103) is a potent and selective inhibitor of the enzyme FAAH, which catalyzes the intracellular hydrolysis of bioactive fatty acid ethanol amides such as anandamide. There are reports that URB-597 increases anandamide levels in the brain of rats and wild-type mice. (The product is for research purpose only.)
References
- Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
- Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): Effects on anandamide and oleoylethanolamide deactivation
- Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597) (a review)
- The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs (a review)
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