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CAS RN: 129453-61-8 | Product Number: F1144


Purity: >98.0%(HPLC)
  • (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol
  • ICI 182780
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≥20  3  
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Product Number F1144
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__3__2H__4__7F__5O__3S = 606.78  
Physical State (20 deg.C) Solid
CAS RN 129453-61-8
Reaxys Registry Number 7734375
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]25 +108 to +115 deg(365nm, C=2, methanol)
Properties (reference)
Solubility in water Insoluble
Degree of solubility in water 0.00001 g/l   25 °C
Solubility (soluble in) Ethanol,Methanol
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P273 : Avoid release to the environment.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P391 : Collect spillage.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# KG7623000
Transport Information:
UN Number UN3077
Class 9
Packing Group III
H.S.code* 2937.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Fulvestrant: An Estrogen Receptors Antagonist with a Unique Structure and Mode of Action

Many breast cancers have estrogen receptors (ERs) and the growth of these tumors can be stimulated by estrogen. ER antagonists bind to ER and downregulate the ER protein in breast cancer cells. Fulvestrant (ICI 182,780) is an ER antagonist with a unique structure and mode of action. It not only binds competitively to the ER with high affinity, but also acts as a degradation inducer of ER with its long alkyl side chain. Therefore, fulvestrant has been reported to help circumvent resistance to “pure” ER antagonists, such as tamoxifen citrate [T2510]. For your reference, [D5471] is a key synthetic intermediate of fulvestrant. (The product is for research purpose only.)


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