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CAS RN: 29094-61-9 | Product Number: G0369
Glipizide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[4-(3-Cyclohexylureidosulfonyl)phenethyl]-5-methyl-2-pyrazinecarboxamide
Product Documents:
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|---|---|---|---|---|---|
| 1G |
A$149.00
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6 | 4 | It can be shipped in about 2 weeks after ordering | |
| 5G |
A$465.00
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8 | 4 | It can be shipped in about 2 weeks after ordering |
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| Product Number | G0369 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__7N__5O__4S = 445.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 29094-61-9 |
| Reaxys Registry Number | 903495 |
| PubChem Substance ID | 125307849 |
| SDBS (AIST Spectral DB) | 52971 |
| Merck Index (14) | 4442 |
| MDL Number | MFCD00072159 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 206 °C |
GHS
Related Laws:
| RTECS# | YS7640000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Glipizide: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Glipizide belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. In addition, glipizide is characterized by poor solubility in water. Therefore, it has been studied to improve the solubility and bioavailability of drug. (The product is for research purpose only. (The product is for research purpose only.)
References
- Glipizide: a review of its pharmacological properties and therapeutic use
- The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells
- Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
- Enhancement of the dissolution rate and bioavailability of glipizide through cyclodextrin inclusion complex
- Development of a controlled release low dose class II drug-Glipizide
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
- Simultaneous estimation of six anti-diabetic drugs-glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay
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