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CAS RN: 102518-79-6 | Product Number: H1700
(-)-Huperzine A
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Purity: >98.0%(HPLC)
Synonyms:
- (5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
Documents:
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| 10MG |
A$574.00
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| 100MG |
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|
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* Chem-Supply Pty Ltd (Phone: 08-8440-2000 / email: info@chemsupply.com.au)
| Product Number | H1700 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8N__2O = 242.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 102518-79-6 |
| Reaxys Registry Number | 3592896 |
| Merck Index (14) | 4755 |
| MDL Number | MFCD01714949 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 230.0 to 234.0 °C |
| Specific rotation [a]20/D | -144 to -155 deg(C=0.5, MeOH) |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 232 °C |
| Specific Rotation | -147° (C=0.5,MeOH) |
| Maximum Absorption Wavelength | 313(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | PB9185700 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2939.79-000 |
Application
(-)-Huperzine A: A Potent, Highly Specific and Reversible Inhibitor of Acetylcholinesterase
(-)-Huperzine A (HupA), a Lycopodium alkaloid isolated from the Chinese herb Huperzia Serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). It has been reported that HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action, compared with other AChE inhibitors including donepezil [D4099] and rivastigmine [R0093]. Recently, HupA has been used in Alzheimer's disease and other forms of dementia. (The product is for research purpose only.)
References
- The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
- Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
- The Lycopodium alkaloids (a review)
- Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
- Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research
- Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma
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