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CAS RN: 102518-79-6 | Product Number: H1700

(-)-Huperzine A


Purity: >98.0%(HPLC)
Synonyms:
  • (5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
Documents:
10MG
A$574.00
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100MG
A$3,291.00
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Product Number H1700
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__8N__2O = 242.32  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 102518-79-6
Reaxys Registry Number 3592896
Merck Index (14) 4755
MDL Number

MFCD01714949

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 230.0 to 234.0 °C
Specific rotation [a]20/D -144 to -155 deg(C=0.5, MeOH)
Water max. 3.0 %
Properties (reference)
Melting Point 232 °C
Specific Rotation -147° (C=0.5,MeOH)
Maximum Absorption Wavelength 313(EtOH) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# PB9185700
Transport Information:
UN Number UN1544
Class 6.1
Packing Group II
H.S.code* 2939.79-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
(-)-Huperzine A: A Potent, Highly Specific and Reversible Inhibitor of Acetylcholinesterase

(-)-Huperzine A (HupA), a Lycopodium alkaloid isolated from the Chinese herb Huperzia Serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). It has been reported that HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action, compared with other AChE inhibitors including donepezil [D4099] and rivastigmine [R0093]. Recently, HupA has been used in Alzheimer's disease and other forms of dementia. (The product is for research purpose only.)

References


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