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CAS RN: 112809-51-5 | Product Number: L0248

Letrozole


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-Bis(4-cyanophenyl)methyl-1,2,4-triazole
  • 4,4'-(1,2,4-Triazol-1-ylmethylene)dibenzonitrile
Documents:
1G
A$374.00
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Product Number L0248
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__1N__5 = 285.31  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 112809-51-5
Reaxys Registry Number 6813913
PubChem Substance ID 172089003
Merck Index (14) 5450
MDL Number

MFCD00866241

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 183.0 to 187.0 °C
Properties (reference)
Melting Point 185 °C
Solubility in water Insoluble
Solubility (slightly sol. in) Methanol
Solubility (very slightly) Ethanol
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P405 : Store locked up.
Related Laws:
RTECS# DI4957000
Transport Information:
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Letrozole: A Nonsteroidal, Potent and Selective Aromatase Inhibitor

Letrozole (CGS 20267), exemestane [E0941] and anastrozole [A2370] are third generation, and potent and selective aromatase inhibitors. In postmenopausal women, estrogens are mainly derived from the action of the aromatase which is responsible enzyme for the aromatization of androgens ([A0845] and [T0027]) into estrogens ([E0026] and [E0025]) respectively in the periphery. The growth of the breast cancer is stimulated or maintained by estrogens. Letrozole, exemestane and anastrozole inhibit aromatase and estrogen synthesis, resulting in suppressing tumor growth. (The product is for research purpose only.)

References


PubMed Literature


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