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CAS RN: 223673-61-8 | Product Number: M3567
Mirabegron
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-2-(2-Aminothiazol-4-yl)-N-[4-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]phenyl]acetamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
A$397.00
|
0 | 17 | Contact Us |
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| Product Number | M3567 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4N__4O__2S = 396.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 223673-61-8 |
| Reaxys Registry Number | 11023250 |
| MDL Number | MFCD11100356 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 141.0 to 145.0 °C |
| Specific rotation | -19.0 to -23.0 deg(C=0.5, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.082 g/l |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2934.10-000 |
Application
Mirabegron: A β3-Adrenergic Receptor Agonist
Mirabegron (YM178) is an agonist of the β3-adrenergic receptor (β3-AR) with potent selectivity over the β1- and β2-ARs. There are reports that mirabegron relaxes the detrusor smooth muscle during the storage phase of the urinary bladder fill-void cycle by activating the β3-AR, thereby increasing bladder capacity. In clinical, mirabegron is used for the treatment of symptoms of overactive bladder (OAB). (The product is for research purpose only.)
References
- Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino] ethyl} acetanilide (YM178), a novel selective β3 -adrenoceptor agonist, on bladder function
- Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome (a review)
- Regulation of human adipose tissue activation, gallbladder size, and bile acid metabolism by a β3-adrenergic receptor agonist
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