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CAS RN: 60491-10-3 | Product Number: S0094
Strychnine Sulfate Pentahydrate
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Purity: >97.0%(T)
Synonyms:
Product Documents:
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| Product Number | S0094 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__4__2H__4__4N__4O__4·H__2SO__4·5H__2O = 856.99 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 60491-10-3 |
| Related CAS RN
|
60-41-3 |
| Reaxys Registry Number | 8179430 |
| PubChem Substance ID | 87575709 |
| Merck Index (14) | 8855 |
| MDL Number | MFCD00068328 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Solubility in hot Water | almost transparency |
| Drying loss | 10.5 to 13.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Degree of solubility in water | 29 g/l |
| Solubility (slightly sol. in) | Alcohol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H330 : Fatal if swallowed or if inhaled. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | WL2550000 |
Transport Information:
| UN Number | UN1692 |
| Class | 6.1 |
| Packing Group | I |
| H.S.code* | 2939.79-000 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
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