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CAS RN: 54965-24-1 | Product Number: T2510
Tamoxifen Citrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
A$232.00
|
19 | 0 | It can be shipped in about 2 weeks after ordering | |
| 5G |
A$732.00
|
1 | 0 | It can be shipped in about 2 weeks after ordering |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | T2510 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__9NO·C__6H__8O__7 = 563.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54965-24-1 |
| Related CAS RN
|
10540-29-1 |
| Reaxys Registry Number | 8888650 |
| PubChem Substance ID | 87560062 |
| Merck Index (14) | 9048 |
| MDL Number | MFCD00058321 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 142 °C(dec.) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Methanol, Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | KH2387000 |
Transport Information:
| H.S.code* | 2921.49-000 |
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen [H1693] and endoxifen (4-hydroxy-N-desmethyltamoxifen). Each acts as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, raloxifene, and the prevention of breast cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen and endoxifen (4-hydroxy-N-desmethyltamoxifen). They act as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, Raloxifene, and the Prevention of Breast Cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
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