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CAS RN: 4429-63-4 | Product Number: T3500
Tabersonine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Methyl 5α,12β,19α-2,3,6,7-Tetradehydroaspidospermidine-3-carboxylate
- Methyl (3aR,3a1S,10bR)-3a-Ethyl-3a,3a1,4,6,11,12-hexahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
A$516.00
|
15 | 0 | Contact Us |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | T3500 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4N__2O__2 = 336.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4429-63-4 |
| Reaxys Registry Number | 50163 |
| MDL Number | MFCD28140545 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 89.0 to 93.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 91 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | CJ0150000 |
Transport Information:
| H.S.code* | 2939.79-000 |
Application
Tabersonine: An Indole Alkaloid with Neuroprotective Properties
Tabersonine is an indole alkaloid found in the beans of Voacanga africana, a plant traditionally used for religious purposes in Africa. There are reports that tabersonine exhibits specific and synergistic multiple neuroprotective properties, including inhibition of amyloid beta (Aβ) fibril-induced cytotoxicity.1,2) Tabersonine is also an intermediate in the biological and chemical synthesis of indole alkaloids, including the anticancer agent vincristine [V0129].1,3,4) (The product is for research purpose only.)
References
- 1) Tabersonine Inhibits Amyloid Fibril Formation and Cytotoxicity of Aβ(1-42)
- 2) Natural spirocyclic alkaloids and polyphenols as multi target dementia leads (a review)
- 3) Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
- 4) Vincamine by synthesis and semi-synthesis (a review)
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