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CAS RN: 128-13-2 | Product Number: U0030
Ursodeoxycholic Acid
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Purity: >98.0%(T)
Synonyms:
- 5β-Cholanic Acid-3α,7β-diol
- 3α,7β-Dihydroxy-5β-cholanic Acid
Product Documents:
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| 5G |
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|
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| Product Number | U0030 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__4H__4__0O__4 = 392.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 128-13-2 |
| Reaxys Registry Number | 3219888 |
| PubChem Substance ID | 87577760 |
| SDBS (AIST Spectral DB) | 11242 |
| Merck Index (14) | 9889 |
| MDL Number | MFCD00003680 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(Neutralization titration) | min. 98.0 %(after drying) |
| Melting point | 200.0 to 205.0 °C |
| Specific rotation [a]20/D | + 59.0 to + 62.0 deg(C=4, EtOH) |
| Solubility in EtOH | almost transparency |
| Drying loss | max. 1.0 % |
Properties (reference)
| Melting Point | 203 °C |
| Specific Rotation | 60.5° (C=4,EtOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 20 mg/l 20 °C |
| Solubility (slightly sol. in) | Chloroform |
GHS
Related Laws:
| RTECS# | FZ2000000 |
Transport Information:
| H.S.code* | 2918.19-000 |
Application
Spore Germination Inhibitor
Ursodeoxycholic acid has been reported to inhibit spore germination in Clostridium difficile (Ki = 213 ± 80 μM).1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid
- Ursodeoxycholic acid. A review of its pharmacological properties and therapeutic efficacy (a review)
- A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
- Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited (a review)
- Bile acids: regulation of apoptosis by ursodeoxycholic acid (a review)
- High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids
- High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma
Application
Synthesis of Biaryls
Ursodeoxycholic acid (ursodiol or UDCA) is a main active compound of bile bear which has been widely used in traditional Chinese medicine for the purpose of promoting the flow of bile (choleretic effect). It is a secondary bile acid resulting from bacterial actions in the colon, and is normally present as a minor fraction of the total bile acids in humans. However, it alters bile acid composition, resulting in decreases in the concentration of the more hydrophobic and cytotoxic bile acids. Furthermore, some studies have suggested that ursodeoxycholic acid protects hepatocytes against bile acid-induced apoptosis. Recently, ursodeoxycholic acid is increasingly used for the treatment of cholestatic liver diseases. (The product is for research purpose only.)
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