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CAS RN: 106685-40-9 | Product Number: A2549

Adapalene


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid
Documents:
200MG
€40.00
2   ≥20 
1G
€139.00
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Product Number A2549
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__8H__2__8O__3 = 412.53  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 106685-40-9
Reaxys Registry Number 7393980
PubChem Substance ID 172088913
Merck Index (14) 150
MDL Number

MFCD03106112

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 324 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# QJ1987000
Transport Information:
HS Number 2918999090
Application
Studies on Retinoic Acid Receptors (RARs)
References

Synthesis, Structure-Affinity Relationships, and Biological Activities of Ligands Binding to Retinoic Acid Receptor Subtypes

B. Charpentier, J.-M. Bernardon, J. Eustache, C. Millois, B. Martin, S. Michel, B. Shroot, J. Med. Chem. 1995, 38, 4993.

Recent developments in receptor-selective retinoids

S. Nagpal, R. A.S. Chandraratna, Curr. Pharm. Des. 2000, 6, 919.

In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions

I. Tenaud, A. Khammari, B. Dreno, Exp. Dermatol. 2007, 16, 500.

A review of the use of adapalene for the treatment of acne vulgaris

S. Piskin, E. Uzunali, Ther. Clin. Risk Manage. 2007, 3, 621.

Site-specific drug delivery to pilosebaceous structures using polymeric microspheres

A. Rolland, N. Wagner, A. Chatelus, B. Shroot, H. Schaefer, Pharm. Res. 1993, 10, 1738.


PubMed Literature


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