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CAS RN: 104075-48-1 | Product Number: A2956

Atipamezole Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole Hydrochloride
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Product Number A2956
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__6N__2·HCl = 248.75  
Physical State (20 deg.C) Solid
CAS RN 104075-48-1
Related CAS RN 104054-27-5
Reaxys Registry Number 8164642
PubChem Substance ID 354334070
Merck Index (14) 861
MDL Number

MFCD06407819

Specifications
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 218.0 to 222.0 °C
Properties (reference)
Melting Point 220 °C
Solubility in water Soluble
Solubility (soluble in) Ethanol
Solubility (insoluble in) Acetone
GHS
Related Laws: / Compliance with laws, Regulations
RTECS# NI6139000
Transport Information:
HS Number 2933299090
Application
Atipamezole: An α2-Adrenoceptor Antagonist

Atipamezole hydrochloride is a potent and selective α2-adrenoceptor antagonist with an imidazole structure. In animals, it promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. The α21 selectivity ratio are considerably higher than those of yohimbine hydrochloride [Y0002]. Unlike many other α2-adrenoceptor antagonists, atipamezole has negligible affinity for 5-HT1A receptors. Atipamezole hydrochloride is used for the reversal of an α2-agonist (e.g. xylazine hydrochloride [X0059]) induced sedation in animals. (The product is for research purpose only.)

References


PubMed Literature


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