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Published TCIMAIL newest issue No.198
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CAS RN: 330784-47-9 | Product Number: A3476
Avanafil
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Purity: >98.0%(T)(HPLC)
Synonyms:
- TA-1790
- (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€75.00
|
1 | 37 |
|
| 5G |
€249.00
|
Contact Us | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3476 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__6ClN__7O__3 = 483.96 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 330784-47-9 |
| Reaxys Registry Number | 11746013 |
| MDL Number | MFCD11977961 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 163.0 to 167.0 °C |
| Specific rotation | -62.0 to -72.0 deg (C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 165 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Avanafil: A Potent and Highly Selective Inhibitor of Phosphodiesterase-5 (PDE-5)
Avanafil is a potent and highly selective inhibitor of phosphodiesterase-5 (PDE-5), which is the predominant PDE isoenzyme in human corpora cavernosa. In there, nitric oxide (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP. Avanafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum. There are reports that avanafil has a favorable PDE-5 selectivity profile compare to that of other PDE-5 inhibitors, such as sildenafil citrate [S0986]. (The product is for research purpose only.)
References
- Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction
- PDE5 inhibitors: considerations for preference and long-term adherence (a review)
- Development and validation of RP-HPLC method for simultaneous estimation of avanafil and dapoxentine hydrochloride in bulk and dosage form
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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