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Published TCIMAIL newest issue No.198
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CAS RN: 55-98-1 | Product Number: B1022
1,4-Butanediol Dimethanesulfonate
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Purity: >97.0%(T)
Synonyms:
- Busulfan
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€104.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B1022 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__1__4O__6S__2 = 246.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 55-98-1 |
| Reaxys Registry Number | 1791786 |
| PubChem Substance ID | 87563973 |
| SDBS (AIST Spectral DB) | 10191 |
| Merck Index (14) | 1505 |
| MDL Number | MFCD00007562 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystaline |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 114.0 to 118.0 °C |
Properties (reference)
| Melting Point | 118 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H350 : May cause cancer. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-250-2 |
| RTECS# | EK1750000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2905399590 |
Application
Busulfan: A Bifunctional Antitumor Alkylating Agent
Busulfan (1,4-butanediol dimethanesulfonate) is a bifunctional antitumor alkylating agent. Busulfan produces a greater degree of DNA-protein and DNA interstrand crosslinking, and thus may effectively induce DNA damage which may play an important role in the cytotoxicity. Busulfan has been used widely for the treatment of chronic myelogenous leukemia, and is currently used in the myeloablative conditioning regimen before hematopoietic stem cell transplantation. (The product is for research purpose only.)
References
- Toxicological review of busulfan (Myleran)
- Comparison of the mechanism of action of busulfan with hepsulfam, a new antileukemic agent, in the L1210 cell line
- An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the american society of hematology (a review)
- DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect
- Busulfan in hematopoietic stem cell transplantation (a review)
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