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CAS RN: 54925-64-3 | Product Number: B1043

1-(tert-Butyldimethylsilyl)imidazole [tert-Butyldimethylsilylating Agent]

Purity: >98.0%(T)
2   7  
5   6  

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Product Number B1043
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__9H__1__8N__2Si = 182.34  
Physical State (20 deg.C) Liquid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 54925-64-3
Reaxys Registry Number 606695
PubChem Substance ID 87563992
SDBS (AIST Spectral DB) 21696
MDL Number


Appearance Colorless to Almost colorless clear liquid
Purity(Nonaqueous Titration) min. 98.0 %
Effect test of GC derivalization Effective as derivatization agent Estradiol, Cholesterol
Properties (reference)
Boiling Point 155 °C/77 mmHg
Flash point 81 °C
Specific Gravity (20/20) 0.86
Refractive Index 1.48
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
EC Number 259-398-1
Transport Information:
HS Number 2933299090
t-Butyldimethylsilylation of Alcohols using TBS Reagents

1)Deprotection of Silyl Ethers Using ZnBr2 and H2O in CH2Cl2

R. D. Crouch, J. M. Polizzi, R. A. Cleiman, J. Yi, C. A. Romany, Tetrahedron Lett. 2002, 43, 7151.

2)Facile Cleavage of Silyl Protecting Groups with Catalytic Amounts of FeCl3

Y. Yang, J. Cui, L. Zhu, Y. Sun, Y. Wu, Synlett 2006, 1260.

3)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

PubMed Literature

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