text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 3543-75-7 | Product Number: B4033

Bendamustine Hydrochloride Hydrate

Purity: >98.0%(T)(HPLC)
  • 5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride Hydrate
1   Contact Us

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

Product Number B4033
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__1Cl__2N__3O__2·HCl·xH__2O = 394.72  
Physical State (20 deg.C) Solid
CAS RN 3543-75-7
Related CAS RN 16506-27-7
Reaxys Registry Number 6031568
PubChem Substance ID 172089039
Merck Index (14) 1034
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %(calcd.on anh.substance)
Melting point 165.0 to 169.0 °C
Water 3.0 to 6.0 %
Properties (reference)
Melting Point 167 °C
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H371 : May cause damage to organs.
H341 : Suspected of causing genetic defects.
H351 : Suspected of causing cancer.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
RTECS# DE1590000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2933998090
Bendamustine Hydrochloride: A Unique Cytotoxic Chemotherapeutic Agent

Bendamustine hydrochloride, an antitumor alkylating agent, was first synthesized in 1963 in the German Democratic Republic. It is a unique cytotoxic chemotherapeutic agent with structural similarities to alkylating agents and antimetabolites containing a purine-like benzimidazole ring, but which is non-cross-resistant with alkylating agents. Bendamustine form covalent bonds with electron-rich nucleophilic moieties, resulting in interstrand DNA crosslinks. This covalent linkage can lead to cell death via several pathways. Recently, bendamustine is re-evaluated as an antitumor agent, and widely used for the treatment of indolent non-Hodgkin's lymphoma (NHL) and mantle cell lymphoma (MCL). (The product is for research purpose only.)


Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines

D. Strumberg, A. Harstrick, K. Doll, B. Hoffmann, S. Seeber, Anticancer Drugs, 1996, 7, 415.

Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with

L. M. Leoni, B. Bailey, J. Reifert, H. H. Bendall, R. W. Zeller, J. Corbeil, G. Elliott, C. C. Niemeyer, Clin. Cancer Res. 2008, 14, 309.

Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling

G. Roué, M. López-Guerra, P. Milpied, P. Pérez-Galán, N. Villamor, E. Montserrat, E. Campo, D. Colomer, Clin. Cancer Res. 2008, 14, 6907.

Bendamustine: rebirth of an old drug (a review)

B. D. Cheson, M. J. Rummel, J. Clin. Oncol. 2009, 27, 1492.

Stability-Indicating LC Method for the Estimation of Bendamustine Hydrochloride and its Related Impurities

S. Kasa, M. R. S. Reddy, R. S. Kadaboina, V. Murki, V. S. Mulukutla, J. Chromatogr. Sci. 2014, 52, 573.

PubMed Literature

Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents