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CAS RN: 16695-22-0 | Product Number: B4136


Purity: >98.0%(HPLC)(N)
  • N,N-Bis[2-(tosyloxy)ethyl]-p-toluenesulfonamide
1   6  
1   ≥20 

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Product Number B4136
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__2__5H__2__9NO__8S__3 = 567.69  
Physical State (20 deg.C) Solid
CAS RN 16695-22-0
Reaxys Registry Number 2406580
PubChem Substance ID 253660357
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 93.0 to 97.0 °C
Properties (reference)
Melting Point 95 °C
Solubility (soluble in) Methanol
Pictogram Pictogram
Signal Word Warning
Hazard Statements H317 : May cause an allergic skin reaction.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 : Avoid release to the environment.
P280 : Wear protective gloves.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
HS Number 2935909099
A Useful Reagent for the Synthesis of Piperazines


Synthesis of 1-Cyclohexyl-4-tosylpiperazine
N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide (B4136, 5.83 g, 10.3 mmol), K2CO3 (P1748, 8.00 g, 58.0 mmol), cyclohexylamine (C0494, 0.99 g, 10.0 mmol), and anhydrous CH3CN (50 mL) are added to a round-bottom flask. The mixture is heated to reflux under an N2 atmosphere for 12 h. The mixture is cooled to r.t. and filtered. The filtrate is concentrated, and the residue is purified by flash chromatography (SiO2, CH2Cl2-CH3OH-Et3N as eluent) to give 1-cyclohexyl-4-tosylpiperazine as a white solid in 83% yield (2.67 g).


PubMed Literature


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