CAS RN: 16695-22-0 | Product Number: B4136
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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
|Appearance||White to Almost white powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Purity(with Total Nitrogen)||min. 98.0 %|
|Melting point||93.0 to 97.0 °C|
|Melting Point||95 °C|
|Solubility (soluble in)||Methanol|
|Hazard Statements||H317 : May cause an allergic skin reaction.
H413 : May cause long lasting harmful effects to aquatic life.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 : Avoid release to the environment.
P280 : Wear protective gloves.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide (B4136, 5.83 g, 10.3 mmol), K2CO3 (P1748, 8.00 g, 58.0 mmol), cyclohexylamine (C0494, 0.99 g, 10.0 mmol), and anhydrous CH3CN (50 mL) are added to a round-bottom flask. The mixture is heated to reflux under an N2 atmosphere for 12 h. The mixture is cooled to r.t. and filtered. The filtrate is concentrated, and the residue is purified by flash chromatography (SiO2, CH2Cl2－CH3OH－Et3N as eluent) to give 1-cyclohexyl-4-tosylpiperazine as a white solid in 83% yield (2.67 g).
- One-Step Cyclization: Synthesis of N-Heteroalkyl-N′-tosylpiperazines
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