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Published TCIMAIL newest issue No.198
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CAS RN: 298-46-4 | Product Number: C1095
Carbamazepin
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Purity: >97.0%(HPLC)(N)
Synonyms:
- 5H-Dibenzo[b,f]azepine-5-carboxamide
- Carbamazepine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10G |
€51.00
|
6 | 28 |
|
| 25G |
€91.00
|
6 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C1095 |
Purity / Analysis Method 
|
>97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__5H__1__2N__2O = 236.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 298-46-4 |
| Reaxys Registry Number | 1246090 |
| PubChem Substance ID | 87566126 |
| SDBS (AIST Spectral DB) | 16056 |
| Merck Index (14) | 1781 |
| MDL Number | MFCD00005073 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 188.0 to 193.0 °C |
| Solubility in Methanol | within very faint turbidity |
Properties (reference)
| Melting Point | 191 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide, Chloroform, Acetone, Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P314 : Get medical advice/ attention if you feel unwell. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 206-062-7 |
| RTECS# | HN8225000 |
Transport Information:
| HS Number | 2933998090 |
Application
Carbamazepine: A Nerve Stabilizer
Carbamazepine (carbamazepin) stabilizes hyper excited nerve membranes, inhibits repetitive neuronal discharges, and reduces synaptic propagation of excitatory impulses. Although, the mechanisms of action of carbamazepine are not completely understood, but it has been reported that carbamazepine prevents the repetitive firing of sodium-dependent action potentials in depolarized neurons via voltage-dependent blockade of sodium channels. Recent studies shows that carbamazepine-induced Stevens-Johnson syndrome is associated with a gene polymorphism of Human leukocyte antigen, HLA-B*1502. On the other hand, the removal of carbamazepine is a problem in the wastewater treatment plants. (The product is for research purpose only.)
References
- Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications
- Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation
- Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-02 (a review)
- Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations (a review)
- Carbamazepine and diclofenac: Removal in wastewater treatment plants and occurrence in water bodies (a review)
- Determination of Carbamazepine and Its Metabolites in Aqueous Samples Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry
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