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Published TCIMAIL newest issue No.198
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CAS RN: 7081-44-9 | Product Number: C2244
Cloxacillin Sodium Salt Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€39.00
|
2 | ≥40 |
|
| 5G |
€124.00
|
18 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2244 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__7ClN__3NaO__5S·H__2O = 475.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 7081-44-9 |
| Related CAS RN | 61-72-3&642-78-4 |
| Reaxys Registry Number | 5403885 |
| PubChem Substance ID | 87560263 |
| SDBS (AIST Spectral DB) | 52169 |
| MDL Number | MFCD00150735 |
Specifications
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Specific rotation [a]20/D | +160 to +169 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | 3.0 to 5.3 % |
Properties (reference)
| Specific Rotation | 164° (C=1,H2O) |
GHS
Related Laws:
| RTECS# | XH8750000 |
Transport Information:
| HS Number | 2941100000 |
Application
Cloxacillin Sodium: A β-Lactamase-Resistant Penicillin
Cloxacillin sodium, an isoxazolyl penicillin, is chemically synthesized from 6-APA [A0800]. Cloxacillin has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria, the same as penicillin G [P1770] [P1772]. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, cloxacillin, oxacillin [O0353] and methicillin are resistant to the enzymes (β-lactamases) which produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins, due to theirs large side-chain, which does not allow the β-lactamases to bind. However, with the widespread use of cloxacillin, antibiotic-resistant strains called cloxacillin-resistant Staphylococcus aureus have become increasingly prevalent worldwide.
References
- Sodium cloxacillin (a review)
- A survey of the kinetic parameters of class C β-lactamases. Penicillins
- Contributions of the AmpC β-lactamase and the acrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to β-lactams
- Solubility of Cloxacillin Sodium in Different Binary Solvents
- Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases
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