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CAS RN: 59729-32-7 | Product Number: C2370

Citalopram Hydrobromide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide
Documents:
1G
€47.00
4   ≥20 
5G
€150.00
5   ≥20 

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Product Number C2370
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__1FN__2O·HBr = 405.31  
Physical State (20 deg.C) Solid
CAS RN 59729-32-7
Related CAS RN 59729-33-8
Reaxys Registry Number 5368282
PubChem Substance ID 125307911
Merck Index (14) 2318
MDL Number

MFCD02101306

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 183 °C(dec.)
GHS
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 261-890-6
RTECS# NP6406750
Transport Information:
HS Number 2932990090
Application
Citalopram Hydrobromide: A Selective Serotonin Reuptake Inhibitor (SSRI)

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). It is a racemic bicyclic phthalane derivative consisting of a 1:1 mixture of the R(-)- and S(+)[E0958] -enantiomers. The mechanism of action of citalopram HBr as an antidepressant is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT) [S0370].  In vitro and in vivo studies suggest that citalopram a highly SSRI with minimal effects on norepinephrine (NA) [A0906] and dopamine (DA) [A0305] neural reuptake. In additon, citalopram has no antagonistic activity towards DA, NA, 5-HT, histamine [H0146, H0147], GABA [A0282], acetylcholine [A0084, chloride], and morphine receptors. Although, the inhibition primarily due to the active S(+)-enantiomer, it is reported that the R(-)-enantiomer counteracts the activity of the S(+)[E0958] -enantiomer. (The product is for research purpose only.)

References


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