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Published TCIMAIL newest issue No.198
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CAS RN: 69-09-0 | Product Number: C2481
Chlorpromazine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€32.00
|
9 | ≥100 |
|
| 25G |
€105.00
|
4 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2481 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9ClN__2S·HCl = 355.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 69-09-0 |
| Related CAS RN | 50-53-3 |
| Reaxys Registry Number | 3779989 |
| PubChem Substance ID | 125307954 |
| Merck Index (14) | 2185 |
| MDL Number | MFCD00012654 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 195.0 to 199.0 °C |
Properties (reference)
| Melting Point | 197 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol, Ethanol |
| Solubility (insoluble in) | Ether, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H330 : Fatal if inhaled. H301 : Toxic if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P273 : Avoid release to the environment. P260 : Do not breathe dust. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-701-3 |
| RTECS# | SO1750000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2934309090 |
Application
Biofilm research
References
- Antifungal activity of promethazine and chlorpromazine against planktonic cells and biofilms of Cryptococcus neoformans/Cryptococcus gattii complex species
- Laser-Irradiated Chlorpromazine as a Potent Anti-Biofilm Agent for Coating of Biomedical Devices
Application
Chlorpromazine Hydrochloride: A Dopamine Inhibitor with Antipsychotic Activity
Chlorpromazine hydrochloride is a phenothiazine antipsychotic agent. The precise mechanism of actions is not fully understood. However, chlorpromazine works as a dopamine inhibitor, and the antagonism central dopaminergic function may be related to the therapeutic effect in psychotic conditions. Chlorpromazine can also produce α-adrenergic receptor antagonist action which may produce hypotension. Besides, it is reported that UV irradiation of chlorpromazine produces reactive free radicals which have DNA damaging properties. (The product is for research purpose only.)
References
- Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- Expression and pharmacological characterization of the human D3 dopamine receptor
- Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors
- Review of the genotoxic properties of chlorpromazine and related phenothiazines
- Fifty years chlorpromazine: a historical perspective (a review)
- Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
- Extraction and determination of trace amounts of chlorpromazine in biological fluids using hollow fiber liquid phase microextraction followed by high-performance liquid chromatography
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