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Published TCIMAIL newest issue No.198
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CAS RN: 168555-66-6 | Product Number: C3009
Combretastatin A4 Phosphate Disodium Salt
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Purity: >98.0%(HPLC)
Synonyms:
- Fosbretabulin Disodium Salt
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€93.00
|
1 | 30 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3009 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9Na__2O__8P = 440.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 168555-66-6 |
| PubChem Substance ID | 354333373 |
| MDL Number | MFCD00943911 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2919900090 |
Application
Antitumor Compound, Combretastatin A4 Phosphate (CA4P)
Combretastatin A4 phosphate (CA4P), a water-soluble antitumor prodrug of Combretastatin A4, is converted to Combretastatin A4 by metabolism. CA4P inhibits microtubule polymerization, thereby inducing mitotic arrest and apoptosis in endothelial cells. It has been reported that CA4P has significant effects on tumor vascularization by disrupting vascular endothelial cadherin.
References
- Antineoplastic agents. 322. Synthesis of combretastatin A-4 prodrugs
- Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
- Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
PubMed Literature
Documents
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