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CAS RN: 31251-41-9 | Product Number: C3181
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
![Chemical Structure of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one](/medias/C3181.jpg?context=bWFzdGVyfHJvb3R8NDY4Nzh8aW1hZ2UvanBlZ3xhREJqTDJoaVl5ODRPVEl3T0RFMk9EYzNOVGs0TDBNek1UZ3hMbXB3Wnd8ZWIwODRjMzM1NTcwOTliYWMwYjJmMjY1MzYyMDMyNDYyMTI1NDgxZDI3YzBlZTg5Mzc3YTAxZjQzZGIxZWZmYQ "8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one")
![Thumbnail of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one](/medias/C3181.jpg?context=bWFzdGVyfHJvb3R8MTQ2MzJ8aW1hZ2UvanBlZ3xhRFU0TDJnNVl5ODRPVE0wTWpNek1EYzVPRE00TDBNek1UZ3hMbXB3Wnd8ZjI4MTk0ZWIzMzY4YjhiNmY4OTM5NjRiNGVlYzU1ZmFhNzdkOTA5MGUwNWFjZjUxZjM0MDZkMWRkMzY1Zjc2Yg)
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![8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one")
Purity: >98.0%(GC)(T)
Synonyms:
- 8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€76.00
|
1 | 1 |
|
| 25G |
€243.00
|
2 | 2 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3181 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__4H__1__0ClNO = 243.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 31251-41-9 |
| Reaxys Registry Number | 1465917 |
| PubChem Substance ID | 354333387 |
| MDL Number | MFCD00800222 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 105 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
A Related Substance of Loratadine and Desloratadine
The reagent is a related substance of loratadine [L0223] and desloratadine [D3787] which are histamine receptor antagonists.
References
- Hydroxylated metabolites of loratadine: an example of conformational diastereomers due to atropisomerism
- LC determination of loratadine and related impurities
- Capillary electrophoresis determination of loratadine and related impurities
- Rapid separation of desloratadine and related compounds in solid pharmaceutical formulation using gradient ion-pair chromatography
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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