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Published TCIMAIL newest issue No.198
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CAS RN: 470-37-1 | Product Number: C3460
Cinobufagine
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Purity: >98.0%(HPLC)
Synonyms:
- 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-Acetate
- Cinobufagin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€168.00
|
2 | 5 |
|
| 100MG |
€504.00
|
2 | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3460 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__4O__6 = 442.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 470-37-1 |
| Reaxys Registry Number | 64587 |
| PubChem Substance ID | 354335510 |
| MDL Number | MFCD00058625 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 213.0 to 217.0 °C |
| Specific rotation [a]20/D | -3.0 to -5.0 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 215 °C |
| Specific Rotation | -36° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 295 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P260 : Do not breathe dust. P262 : Do not get in eyes, on skin, or on clothing. P280 : Wear protective gloves/ protective clothing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| RTECS# | EI2955000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2932990090 |
Application
Cinobufagine: An Antitumor Component of Cinobufacini, a Chinese Traditional Medicine
Cinobufagine (or cinobufagin) is an active component of Cinobufacini (Huachansu), which is a Chinese traditional medicine for various cancers prepared from the skin of the toad Bufo bufo gargarizans Cantor. Pharmacological experiments have demonstrated the antitumor activities of cinobufagine, such as inhibition of cell proliferation, induction of cell differentiation, induction of apoptosis, disruption of the cell cycle, inhibition of cancer angiogenesis, resensitization of cancer cells to chemotherapeutic agents, and regulation of the immune response. (The product is for research purpose only.)
References
- Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells
- Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells
- Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor (a review)
- Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, Liu-Shen-Wan, by liquid chromatography
- Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC
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