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CAS RN: 22978-25-2 | Product Number: C4016
GW 9662
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Chloro-5-nitro-N-phenylbenzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€84.00
|
1 | 27 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | C4016 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__9ClN__2O__3 = 276.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 22978-25-2 |
| Reaxys Registry Number | 2749539 |
| MDL Number | MFCD01215270 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 159.0 to 163.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 161 °C |
GHS
Related Laws:
| RTECS# | CV2465500 |
Transport Information:
| HS Number | 2924297099 |
Application
GW 9662: A Peroxisome Proliferator-Activated Receptor γ (PPARγ) Antagonist
Peroxisome proliferator-activated receptor γ (PPARγ) antagonist is a druggable target for the treatment of not only type 2 diabetes and obesity, but also cancer. It has been reported that the PPARγ antagonist GW9662 binds to the ligand binding site of PPARγ and results in the inhibition of adipocyte differentiation.1) GW9662 prevents the activation of PPARγ and inhibits the growth of human breast tumor cell lines.2,3) In addition, GW9662 stimulates the differentiation of M2c macrophages and induces the expression of growth arrest specific 6 (Gas6).4) (The product is for research use only.)
References
- 1) Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662
- 2) GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation
- 3) The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity (a review)
- 4) The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
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