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CAS RN: 28230-32-2 | Product Number: D2039

3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
  • 3-Hydroxy-4-ketobenzotriazine
Documents:
10G
€63.00
2   ≥20 
25G
€115.00
Contact Us ≥20 

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Note:

This product cannot be shipped to Germany.

Product Number D2039
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__7H__5N__3O__2 = 163.14  
Physical State (20 deg.C) Solid
CAS RN 28230-32-2
Reaxys Registry Number 609382
SDBS (AIST Spectral DB) 18936
MDL Number

MFCD00042803

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 181 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
EC Number 248-916-1
Transport Information:
HS Number 2933998090
Application
An Efficient Additive for Condensation Reactions

D2039

Experimental procedure: 1 (60.6 mg, 0.21 mmol), 2 (85.5 mg, 0.20 mmol) and 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine (0.22 mmol) are dissolved in 1 mL of TFE/CHCl3 (1:3 v/v). To the mixture is added a solution of EDC (34.2 mg, 0.22 mmol) of in 1 mL of TFE/CHCl3 (1:3 v/v), and the whole mixture is stirred at rt overnight. The resulting mixture is diluted with 25 mL of EtOAc, washed with 1 mol/L HCl (2 × 10 mL), 10% NaHCO3 (2 × 10 mL), and brine (2 × 10 mL), and dried over MgSO4. After removal of solvent, the solid is then stirred with 2 mL of 50% TFA in a dichloromethane solution for 2 h to deblock the Boc-group. The TFA and CH2Cl2 are then removed in vacuo, 20 mL of anhydrous ether is added to the oily residue, and the mixture is stored overnight. The white precipitate which has separated is collected by filtration and washed with ether to afford 3 (96% over 2 steps).

References


Application
Solid Phase Peptide Synthesis

References


PubMed Literature


TCIMAIL
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