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Published TCIMAIL newest issue No.201
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CAS RN: 993-12-4 | Product Number: D2159
Dimethylthiophosphinoyl Chloride
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Purity: >97.0%(GC)
Synonyms:
- Chlorodimethylphosphine Sulfide
- Dimethylphosphinothioyl Chloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
83,00 €
|
1 | 12 |
|
|
| 5G |
316,00 €
|
Contact Us | 7 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D2159 |
Purity / Analysis Method 
|
>97.0%(GC) |
| Molecular Formula / Molecular Weight | C__2H__6ClPS = 128.55 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 993-12-4 |
| Reaxys Registry Number | 906761 |
| PubChem Substance ID | 87568600 |
| MDL Number | MFCD00014454 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 78 °C/15 mmHg |
| Specific Gravity (20/20) | 1.22 |
| Refractive Index | 1.54 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P261 : Avoid breathing mist or vapours. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 213-606-7 |
Transport Information:
| UN Number | UN3265 |
| Class | 8 |
| Packing Group | II |
| HS Number | 2931599090 |
Application
A Condensing Reagent for the Peptide Synthesis in Alcohol Solvents
Experimental procedure1): A solution of Cbz-Asn-OH (79.8 mg, 0.3 mmol) and triethylamine (41.8 µL, 0.3 mmol) in methanol (2.6 mL) is cooled to -20 °C, and treated with a solution of Dimethylthiophosphinoyl Chloride (Mpt-Cl, 38 mg, 0.3 mmol) in methanol (0.9 mL), and the mixture stirred for 20 min. The solution is added to a solution of the tetrapeptide (1, 133.3 mg, 0.3 mmol) and triethylamine (41.8 µL, 0.3 mmol) in methanol (7.0 mL) and water (3.0 mL) at -20 °C. After the mixture has been stirred for 40 minutes the Cbz-Asn-OMpt solution and triethylamine (0.3 mmol each) are added and the stirring continued at -20 °C for 2 h and at 0 °C for 48 h. The precipitate is filtered and washed with chloroform, ethanol, water, and ether, and dried to give the pentapeptide (2, 173.7 mg, 84 %).
Peptide Synthesis, Glycosylation
References
- Peptide Synthesis
- Novel Glycosylation Reaction
- N-Acylation of Aminosugars
Application
Peptide Synthesis, Glycosylation
References
- Peptide Synthesis
- Novel Glycosylation Reaction
- N-Acylation of Aminosugars
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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