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CAS RN: 57808-66-9 | Product Number: D4125

Domperidone


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
Documents:
200MG
€86.00
2   10  
1G
€298.00
2   14  

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Product Number D4125
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__4ClN__5O__2 = 425.92  
Physical State (20 deg.C) Solid
CAS RN 57808-66-9
Reaxys Registry Number 903774
PubChem Substance ID 135727073
Merck Index (14) 3418
MDL Number

MFCD00069256

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 243 °C(dec.)
Solubility in water Insoluble
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 260-968-7
RTECS# DE2275900
Transport Information:
HS Number 2933998090
Application
Domperidone: A Peripherally Acting Dopamine D2 Receptor Antagonist

Domperidone is a peripherally acting dopamine D2 receptor antagonist with antiemetic properties similar to those of metoclopramide [M2218] . Unlike metoclopramide, however, domperidone does not readily cross the blood-brain barrier. Its antiemetic effect may be due to a combination of gastrokinetic effects and an antagonism of dopamine D2 receptor. Since the 2000s, the US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. (The product is for research purpose only.)

References


PubMed Literature


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