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Published TCIMAIL newest issue No.199
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CAS RN: 62013-04-1 | Product Number: D5495
Dirithromycin
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Purity: >98.0%(HPLC)(N)
Synonyms:
- [9S(R)]-9-Deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)ethylidene]oxy]erythromycin
- LY-237216
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€107.00
|
1 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5495 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__4__2H__7__8N__2O__1__4 = 835.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 62013-04-1 |
| Reaxys Registry Number | 6842524 |
| PubChem Substance ID | 468591372 |
| Merck Index (14) | 3354 |
| MDL Number | MFCD00865041 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | -85.0 to -90.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 188 °C |
| Specific Rotation | -88° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | JG5806477 |
Transport Information:
| HS Number | 2941500000 |
Application
Dirithromycin: A Macrolide Antibiotic with Outstanding Activity against Campylobacter
Dirithromycin is a macrolide antibiotic derived from erythromycin [E0751]. Dirithromycin is a prodrug, and is hydrolyzed in vivo to its major active metabolite, erythromycilamine.1) Although the antimicrobial spectrum of dirithromycin is similar to that of erythromycin, it reportedly has outstanding activity against Campylobacter.2) In addition, erythromycin inhibits cytochrome P450 isoform 3A4 (CYP3A4), but dirithromycin and azithromycin [A2076] neither inhibit CYP3A4 nor are implicated in clinically significant drug-drug interactions.3) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (a review)
- 4) Analysis of macrolide antibiotics (a review)
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