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Published TCIMAIL newest issue No.198
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CAS RN: 75507-68-5 | Product Number: F0736
Flupirtine Maleate Salt
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-3-(ethoxycarbonylamino)-6-(4-fluorobenzylamino)pyridine Maleate Salt
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€48.00
|
4 | 10 |
|
| 1G |
€298.00
|
2 | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0736 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__7FN__4O__2·C__4H__4O__4 = 420.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 75507-68-5 |
| Related CAS RN | 56995-20-1 |
| Reaxys Registry Number | 6467047 |
| PubChem Substance ID | 125307841 |
| Merck Index (14) | 4190 |
| MDL Number | MFCD00941415 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C |
| Maximum Absorption Wavelength | 343 nm (CH__3CN) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 278-225-0 |
| RTECS# | EY8555800 |
Transport Information:
| HS Number | 2933399990 |
Application
Flupirtine Maleate: An Aminopyridine Potassium Kv7 (KCNQ) Channel Opener
Flupirtine maleate is an aminopyridine potassium Kv7 (KCNQ) channel opener. Flupirtine maleate also acts as N-methyl-D-aspartate (NMDA) receptor antagonist. Flupirtine maleate acts as a non-opioid centrally acting analgesic agent with muscle tone-reducing activity by reducing the excessive electrical activity that leads to pain states. (The product is for research purpose only.)
References
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension
- Neural KCNQ (Kv7) channels (a review)
- Flupirtine in pain management: pharmacological properties and clinical use (a review)
- Flupirtine, a re-discovered drug, revisited (a review)
- Isolation, identification and characterization of novel process-related impurities in flupirtine maleate
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