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CAS RN: 141505-33-1 | Product Number: L0320


Purity: >98.0%(HPLC)
  • (R)-Simendan
  • 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]propanedinitrile
  • OR-1259
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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

Product Number L0320
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__2N__6O = 280.29  
Physical State (20 deg.C) Solid
CAS RN 141505-33-1
Reaxys Registry Number 6959885
Merck Index (14) 5471
MDL Number


Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D -600 to -650 deg(C=0.5, THF)
Properties (reference)
Melting Point 205 °C
Specific Rotation -627° (C=0.5,THF)
Solubility in water Soluble
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
RTECS# TY1570210
Transport Information:
UN Number UN3439
Class 6.1
Packing Group III
HS Number 2933998090
Levosimendan: A Calcium Sensitizer

Levosimendan, a calcium sensitizer, enhances the calcium sensitivity of contractile proteins by binding to cardiac troponin C.1) In addition, levosimendan has vasodilatory effects that are achieved by stimulation of ATP-dependent potassium channels in vascular smooth muscle, and also has the potential inhibitory effect of phosphodiesterase (PDE) III.2,3) Therefore, levosimendan is used in the treatment of acute and decompensated heart failure.4) (The product is for research purpose only.)


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