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Published TCIMAIL newest issue No.198
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CAS RN: 156897-06-2 | Product Number: L0348
Licofelone
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Purity: >95.0%(HPLC)
Synonyms:
- ML-3000
- 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic Acid
- [6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrol-5-yl]acetic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€165.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0348 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__2ClNO__2 = 379.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 156897-06-2 |
| Reaxys Registry Number | 6823674 |
| MDL Number | MFCD00929900 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 157 °C |
GHS
Related Laws:
| RTECS# | UY7759650 |
Transport Information:
| HS Number | 2933998090 |
Application
Licofelone: A Dual Inhibitor of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)
Licofelone (ML-3000) is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) metabolic pathways of arachidonic acid [A0781], and decreases the production of pro-inflammatory leukotrienes and prostaglandins.1-3) There are reports that licofelone is expected to possess clinical advantages over the selective inhibitors of COX enzyme. Licofelone is considered as a treatment for osteoarthritis. In addition, licofelone induces apoptosis in cancer cells.4,5) (The product is for research purpose only.)
References
- 1) Discovery and development of ML3000 (a review)
- 2) The pharmacological profile of ML3000: a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase (a review)
- 3) Licofelone -A novel analgesic and anti-inflammatory agent (a review)
- 4) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
- 5) Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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