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Published TCIMAIL newest issue No.199
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CAS RN: 192927-63-2 | Product Number: M2479
Moxifloxacin Hydrochloride Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic Acid Hydrochloride Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€77.00
|
Contact Us | 1 |
|
| 1G |
€482.00
|
3 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2479 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4FN__3O__4·HCl·H__2O = 455.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 192927-63-2 |
| Related CAS RN
|
186826-86-8&151096-09-2 |
| Reaxys Registry Number | 8377447 |
| PubChem Substance ID | 354334556 |
| Merck Index (14) | 6291 |
| MDL Number | MFCD00949117 |
Specifications
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -124 to -137 deg(C=0.5, water) |
| Water | 3.0 to 5.0 % |
Properties (reference)
| Melting Point | 240 °C(dec.) |
| Maximum Absorption Wavelength | 338 nm (H__2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | VB1983750 |
Transport Information:
| HS Number | 2933491090 |
Application
Moxifloxacin Hydrochloride: A Fluoroquinolone Antibacterial with a Methoxy Group in the C-8 Position
Moxifloxacin hydrochloride (BAY 12-8039) is a synthetic fluoroquinolone antibacterial agent with in vitro activity against a wide range of Gram-positive and Gram-negative bacteria. The bactericidal action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) in Gram-negative bacteria and topoisomerase IV in Gram-positive bacteria required for bacterial DNA replication, transcription, repair, and recombination. It is reported that the C8-methoxy moiety contributes to enhanced activity and lower selection of resistant mutants of Gram-positive bacteria compared to the C8-H moiety. Therefore, moxifloxacin has improved activity against Gram-positive species (including staphylococci, streptococci, enterococci) compared with ciprofloxacin [ C2510, C2227 (HCl salt)]. Recently, antituberculosis activity of moxifloxacin has been reported. (The product is for research purpose only.)
References
- 1)In vitro Activity of BAY 12-8039, a New 8-Methoxyquinolone
- 2)The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus
- 3)In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis
- 4)Moxifloxacin: A review of its use in the management of bacterial infections
- 5)Simultaneous determination of levofloxacin, gatifloxacin and moxifloxacin in serum by liquid chromatography with column switching
- 6)Optimization of separation and determination of moxifloxacin and its related substances by RP-HPLC
- 7)Solubility of Antibiotics in Different Solvents. 1. Hydrochloride Forms of Tetracycline, Moxifloxacin, and Ciprofloxacin
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