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CAS RN: 110429-36-2 | Product Number: M2645

N-Methyl Paroxetine

Purity: >98.0%(GC)(T)
2   ≥20 
1   ≥20 

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Product Number M2645
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__2__0H__2__2FNO__3 = 343.4  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 110429-36-2
Reaxys Registry Number 768178
PubChem Substance ID 253662337
MDL Number


Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 109.0 to 113.0 °C
Specific rotation [a]20/D -69.0 to -89.0 deg(C=0.01, MeOH)
Properties (reference)
Melting Point 111 °C
Specific Rotation -70° (C=0.01,MeOH)
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
HS Number 2934999090
N-Methyl paroxetine: A Synthetic Precursor of Paroxetine

N-Methyl paroxetine is a synthetic precursor of paroxetine hydrochloride hemihydrate [P1977] which is a 5-hydroxytryptamine (5-HT) uptake inhibitor.


  • Preparation of crystalline paroxetine hydrochloride hemihydrate for use as an antidepressant
    • R. D. Barnes, M. W. Wood-Kaczmar, J. E. Richardson, I. R. Lynch, P. C. Buxton, A. D. Curzons, Eur. Pat. Appl. 1987, EP 223403 A2.
  • Preparation of paroxetine from N-alkyl derivatives.
    • S.-z. Wang, Y. Matsumura, Eur. Pat. Appl. 1997, EP 810225 A1.

PubMed Literature

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