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CAS RN: 51-60-5 | Product Number: N0447

Neostigmine Methyl Sulfate


Purity: >98.0%(N)
Synonyms:
  • (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Methyl Sulfate
  • (3-Hydroxyphenyl)trimethylammonium Methyl Sulfate Dimethylcarbamate
Documents:
5G
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3   ≥20 

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Product Number N0447
Purity / Analysis Method >98.0%(N)
Molecular Formula / Molecular Weight C__1__3H__2__2N__2O__6S = 334.39  
Physical State (20 deg.C) Solid
CAS RN 51-60-5
Related CAS RN 59-99-4
Reaxys Registry Number 3848275
PubChem Substance ID 87573782
SDBS (AIST Spectral DB) 4993
Merck Index (14) 6464
MDL Number

MFCD00011796

Specifications
Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 98.0 %
Melting point 145.0 to 149.0 °C
Solubility in Water almost transparency
Properties (reference)
Melting Point 146 °C
Solubility in water Completely soluble
Solubility (soluble in) Ethanol
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 200-109-5
RTECS# CY1225000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
HS Number 2939790090
Application
競合的な抗コリンエステラーゼ阻害剤

Neostigmine methyl sulfate, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine methyl sulfate has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine methyl sulfate induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine methyl sulfate used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433] (The product is for research purpose only.)

References


PubMed Literature


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