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Published TCIMAIL newest issue No.198
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CAS RN: 82752-99-6 | Product Number: N1030
Nefazodone Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€26.00
|
1 | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1030 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__3__2ClN__5O__2·HCl = 506.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 82752-99-6 |
| Related CAS RN | 83366-66-9 |
| Reaxys Registry Number | 4636943 |
| PubChem Substance ID | 354333934 |
| Merck Index (14) | 6438 |
| MDL Number | MFCD00935760 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C |
| Maximum Absorption Wavelength | 248 nm (MeOH) |
GHS
Related Laws:
| RTECS# | XZ5483009 |
Transport Information:
| HS Number | 2933599590 |
Application
強力な5-HT2A受容体アンタゴニスト，ネファゾドン塩酸塩
Nefazodone hydrochloride acts as a potent antagonist at the postsynaptic serotonin (5-hydroxytryptamine [S0370]; 5-HT) 5-HT2A receptors, and moderately inhibits serotonin and noradrenaline (norepinephrine) [A0906] reuptake. According to in vitro binding studies, nefazodone has no significant affinity for the following receptors: α2- and β-adrenergic, 5-HT1A, cholinergic, dopaminergic, or benzodiazepine. Nefazodone hydrochloride used to use as a synthetically derived phenylpiperazine antidepressant, but was withdrawn from the world pharmaceutical market in 2000s due to its hepatotoxicity. (The product is for research purpose only.)
References
- Nefazodone: preclinical pharmacology of a new antidepressant
- Nefazodone, A review of its pharmacology and clinical efficacy in the management of major depression
- Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4
- In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone
- Rapid and simple methods for quantitative analysis of some antidepressant in pharmaceutical formulations by using first derivative spectrophotometry and HPLC
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