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Published TCIMAIL newest issue No.198
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CAS RN: 101-26-8 | Product Number: P1339
Pyridostigmine Bromide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-(Dimethylcarbamoyloxy)-1-methylpyridinium Bromide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€75.00
|
1 | 10 |
|
| 25G |
€239.00
|
2 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1339 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3BrN__2O__2 = 261.12 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 101-26-8 |
| Related CAS RN | 155-97-5 |
| Reaxys Registry Number | 3764573 |
| PubChem Substance ID | 87575426 |
| Merck Index (14) | 7977 |
| MDL Number | MFCD00079283 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 154 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
| Solubility (insoluble in) | Ether, Acetone, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 202-929-9 |
| RTECS# | UU5270000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2933399990 |
Application
Pyridostigmine Bromide: A Reversible Cholinesterase Inhibitor
Pyridostigmine bromide is a reversible cholinesterase inhibitor which inhibits the hydrolysis of acetylcholine (ACh) by competitive reversible binding to acetylcholinesterase (AChE). Pyridostigmine bromide is not through to enter the brain in significant amounts, and mainly activates peripheral cholinergic nervous system by increasing the concentration of ACh in the nerve through reversible inhibition of its hydrolysis by AChE. Pyridostigmine bromide is used for symptomatic treatment of myasthenia gravis and has been applied as a prophylaxis against nerve agents. (The product is for research purpose only.)
References
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- Treatment of myasthenia gravis: focus on pyridostigmine
- A validated HPLC method for the determination of pyridostigmine bromide, acetaminophen, acetylsalicylic acid and caffeine in rat plasma and urine
- Adsorptive stripping voltammetric determination of pyridostigmine bromide in bulk, pharmaceutical formulations and biological fluid
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