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CAS RN: 518-28-5 | Product Number: P1771
Podophyllotoxin
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Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€44.00
|
1 | 22 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P1771 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__2O__8 = 414.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 518-28-5 |
| Reaxys Registry Number | 99163 |
| PubChem Substance ID | 468592573 |
| Merck Index (14) | 7546 |
| MDL Number | MFCD00075290 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 177.0 to 185.0 °C |
| Specific rotation [a]20/D | -125 to -135 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 181 °C |
| Specific Rotation | -129° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 292 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H310 : Fatal in contact with skin. H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P262 : Do not get in eyes, on skin, or on clothing. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 208-250-4 |
| RTECS# | LV2500000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2932209090 |
Application
Podophyllotoxin: A Lignin with Antineoplastic and Antiviral Properties
Podophyllotoxin is a naturally occurring lignan isolated from Podophyllum peltatum, with important antineoplastic and antiviral properties. Although the exact mechanism of action is unknown, podophyllotoxin is believed to exert its antimitotic effect by binding to tubulin. In addition, podophyllotoxin derivatives, such as etoposide [E0675] and teniposide [T3109], act as topoisomerase II inhibitors and can cause arrest in the cell cycle of tumor at the G2/M stage. (The product is for research purpose only.)
References
- Discovery of podophyllotoxins (a review)
- Podophyllotoxin (a review)
- Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives (a review)
- A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007
- Recent Advances in the Chemistry and Biology of Podophyllotoxins
- Separation, determination, and identification of the diastereoisomers of podophyllotoxin and its esters by high-performance liquid chromatography/tandem mass spectrometry
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