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Published TCIMAIL newest issue No.198
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CAS RN: 23180-57-6 | Product Number: P1876
Paeoniflorin
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Purity: >95.0%(NMR)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€83.00
|
1 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1876 |
| Purity / Analysis Method | >95.0%(NMR) |
| Molecular Formula / Molecular Weight | C__2__3H__2__8O__1__1 = 480.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 23180-57-6 |
| Reaxys Registry Number | 6079909 |
| PubChem Substance ID | 125307355 |
| MDL Number | MFCD00869331 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(qNMR) | min. 95.0 % |
| Specific rotation [a]20/D | -11.0 to -15.0 deg(C=1,MeOHl) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -14° (C=1,MeOH) |
GHS
Related Laws:
| EC Number | 245-476-2 |
| RTECS# | RT1200000 |
Transport Information:
| HS Number | 2938909090 |
Application
Paeoniflorin: The Major Active Component of the Root of Paeonia lactiflora Pallas
Paeoniflorin is the major active component of the root of Paeonia lactiflora Pallas which is a traditional Chinese medicine used for the treatment of pain or inflammatory disorders.1,2) Pharmacological studies suggest that paeoniflorin has diverse effects, including anti-inflammatory,1) anti-hyperglycemic,3) liver-protective,4) neuroprotective,5,6) and anti-proliferative effects.7) (The product is for research purpose only.)
References
- 1) Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses
- 2) Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae Radix extract
- 3) Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora
- 4) Protective effect of paeoniflorin on immunological liver injury induced by bacillus calmette-guerin plus lipopolysaccharide: modulation of tumour necrosis factor-alpha and interleukin-6 mrna
- 5) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists
- 6) Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor
- 7) Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells
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