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Published TCIMAIL newest issue No.198
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CAS RN: 58-14-0 | Product Number: P2037
Pyrimethamine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€20.00
|
1 | ≥100 |
|
| 5G |
€64.00
|
8 | 38 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2037 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__3ClN__4 = 248.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 58-14-0 |
| Reaxys Registry Number | 219864 |
| PubChem Substance ID | 253660065 |
| Merck Index (14) | 7985 |
| MDL Number | MFCD00057350 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 239.0 to 243.0 °C |
Properties (reference)
| Melting Point | 241 °C |
| Maximum Absorption Wavelength | 276 nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 200-364-2 |
| RTECS# | UV8140000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2933599590 |
Application
Pyrimethamine, an inhibitor of dihydrofolate reductase
Pyrimethamine is known as an antagonist of folic acid and has an anti-malarial effect. It inhibits dihydrofolate reductase of bacteria and protozoa and affects cell division by inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid. Its inhibitory effect against human’s dihydrofolate reductase is only 1/1000 in comparison to that of bacteria or protozoa, so that it is considered to be less effective for human. (The product is for research purpose only.)
Related product
Sulfadiazine (S0579)
Related product
Sulfadiazine (S0579)
References
- A 2 : 4-Diamino Pyrimidine in the Treatment of Proguanil-resistant Laboratory Malarial Strains
- Toxoplasmosis (a review)
- Antimalarial compounds: from bench to bedside (a review)
- Effectiveness of Antimalarial Drugs (a review)
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