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CAS RN: 135729-62-3 | Product Number: P2051
Palonosetron Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€75.00
|
1 | 18 |
|
| 1G |
€265.00
|
1 | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2051 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__4N__2O·HCl = 332.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 135729-62-3 |
| Related CAS RN | 135729-61-2 |
| Reaxys Registry Number | 21177207 |
| PubChem Substance ID | 253660260 |
| Merck Index (14) | 6997 |
| MDL Number | MFCD07370072 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -88.0 to -93.0 deg(C=1, CHCl3) |
Properties (reference)
| Melting Point | 307 °C(dec.) |
| Specific Rotation | -89° (C=1,CHCl3) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933499090 |
Application
Palonosetron Hydrochloride: a Selective 5-HT3 Receptor Antagonist (5-HT3-RA)
Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist (5-HT3-RA) with a longer human plasma half-life (-40 h) and a higher binding affinity than older first-generation 5-HT3-RAs.
References
- 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists
- Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis
- Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist
- Palonosetron Exhibits Unique Molecular Interactions with the 5-HT3 Receptor
- Palonosetron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor function
- Pharmacological mechanisms of 5-HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting
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